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KMID : 0391419930030020133
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Korean Journal of Lipidology
1993 Volume.3 No. 2 p.133 ~ p.141
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Effects of Different Dietary Oils on serum and hepatic Lipid Metabolism in Rat Hepatocarcinogenesis
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Abstract
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This study was done to investigate the effects of different dietary oils on serum and hepatic lipid metabolism in carcinogen treated rats. Sixty male Sprague-Dawley rats, weighing 50~60g, were fed three different types of dietary oils, beef
tallow
(BT),
corn oil(CO) and sardine oil (SO) at 15% by weight for 14 weeks. Three weeks after feeding. Rats were intraperitoneally injected with a single dose of diethylnitrosamine (200 mg/kg BW). After five weeks rate were fed 0.02% acetylaminofluorene
containing
diet for 6 weeks and after seven weeks 0.05% phenobarbital containing diet for 7 weeks. At 14th week,, rats were sacrificed serum and hepatic lipids and hepatic lipogenic enzyme activities were determined.
Liver weight and percent liver weight per body weight was significantly increased by carcinogen treatment. Serum TG levels were significantly decreased by carcinogen treatment in all dietary groups whereas hepatic TG levels were increased. Serum
cholesterol, HDL-cholesterol and hepatic cholesterol levels were significantly increased by carcinogen treatment in BT and CO groups whereas not changed by carcinogen treatment in SO group. The analysis of % lipoprotein composition showed that %
VLDL of
SO group was greater than other groups. Especially % VLDL levels were decreased by carcinogen treatment in only CO and SO groups. glucose-6-phosphate dehydrogenase and malic enzyme activities were also significantly increased by carcinogen
treatment in
BT and CO groups whereas decreased in SO group. These data indicate that fish oil differs from beef tallow and corn oil in terms of the changes in serum and hepatic lipid metabolism during hepatic carcinogenesis.
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KEYWORD
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